. 2018 Jul 21;218(11):1746–1752. doi: 10.1093/infdis/jiy463

Table 3.

Association Between Human Papillomavirus Type 16/18 Status Over Time and Probability of Low-Grade Squamous Intraepithelial Lesion Progression

HPV-16/18 Positivity			N=168	Progression to HSIL at Follow-up Visit, No. (%)
Status Over Time	Baseline	Follow-up	No. (%)	Progression to HSIL at Follow-up Visit, No. (%)
Persistent	+	+	54 (32)	38 (70)
Intermittent	+	_	20 (12)	10 (50)
Intermittent	_	+	9 (5)	5 (56)
Always negative	_	_	85 (51)	16 (19)

Abbreviations: HPV, human papillomavirus; HSIL, high-grade squamous intraepithelial lesion.

^aThe difference in probability of low-grade squamous intraepithelial lesion progression between longitudinal HPV-16/18 infection status groups was statistically significant (P < .001).