Table 4.

Unadjusted and Adjusted Cox Proportional Hazard Regression Models Evaluating Predictors of Low-Grade Squamous Intraepithelial Lesion Outcomes

Model and Predictor	Unadjusted HR (95% CI)	P Value	Adjusted HR (95% CI)	P Value
Model 1: Baseline HPV
Baseline HPV-16/18	3.22 (1.93–5.40)	<.001	3.25 (1.90–5.58)	<.001
Baseline non-16/18	2.05 (.82–5.09)	.12	1.72 (.67–4.41)	.26
Age, y
<40	Reference		Reference
40–50	0.52 (.28–1.0)	.05	0.83 (.42–1.63)	.58
>50	1.04 (.61–1.77)	.89	1.54 (.84–2.81)	.16
Male gender	2.24 (.70–7.12)	.17	2.23 (.67–7.43)	.19
HIV	1.82 (.66–5.01)	.25	1.44 (.51–4.10)	.50
Smoking history
Never	Reference		Reference
Former	1.70 (.98–2.96)	.06	1.44 (.79–2.60)	.23
Current	1.36 (.72–2.53)	.34	1.18 (.62–2.23)	.62
Model 2: Longitudinal HPV-16/18 status
Longitudinal HPV-16/18
Persistent	5.57 (3.09–10.04)	<.001	7.00 (3.69–13.27)	<.001
Intermittent	2.14 (1.05–4.37)	.04	2.02 (.97–4.19)	.06
Always negative	Reference		Reference
Age, y
<40	Reference		Reference
40–50	0.52 (.28–.99)	.05	0.88 (.44–1.77)	.72
>50	1.04 (.61–1.77)	.89	1.64 (.88–3.04)	.12
Male gender	2.24 (.70–7.12)	.17	3.23 (.96–10.84)	.06
HIV	1.82 (.66–5.01)	.25	1.72 (.60–4.89)	.31
Smoking history
Never	Reference		Reference
Former	1.26 (.63–2.50)	.51	1.67 (.76–2.48)	.30
Current	0.74 (.39–1.38)	.34	0.82 (.42–1.61)	.57

Abbreviations: CI, confidence interval; HIV, human immunodeficiency virus; HPV, human papillomavirus; HR, hazard ratio.