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. 2018 Oct 19;19:168. doi: 10.1186/s13059-018-1560-8

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — eQTL interactions with drug exposure. a Drug exposure interaction with the CLEC18A eQTL plotted with respect to rs3192882 genotype (left) and drug exposure (right). b The IRF4 motif enriched among eQTLs magnified following drug treatment. Arrows indicate positions of the motif interrupted by interaction SNPs (or SNPs in strong LD). Red and blue indicate SNPs corresponding to magnified and dampened eQTLs respectively. c Concordance of free IL-6 protein interaction effects with drug exposure interaction effects (gray indicates consistent direction)