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. 2018 Oct 20;11:285. doi: 10.1186/s13068-018-1272-z

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© The Author(s) 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 5 — Pentalenene production in S. cerevisiae. a The S. cerevisiae host engineered for the production of antimalarial precursor amorphadiene was re-engineered to produce pentalenene by overexpressing pentalenene synthase (PentS) in a plasmid. ERG10 acetyl-CoA acetyltransferase, IDI1 isoprenyl diphosphate isomerase, ERG20 farnesyl disphosphate synthase. Genes in blue arrows (upc2-1, tHMGR, ERG20 and PentS) are overexpressed. b Production titer and c cell growth (OD₆₀₀) with CSM medium and YEP medium supplemented with 1.8% galactose/0.2% glucose