Fig. 2.

MECP2 and CDKL5 gene variants differ in network architecture. All subplots depicting a statistical comparison significant at a p value of < 0.05 are marked with an asterisk (*). a Covariance matrices of inter-electrode coherence measurements for MECP2 (n = 36) and CDKL5 (n = 4) groups, allowing visualisation of higher-order network function. Each row and each column represent a pair of electrodes. These are arranged into blocks along the axes, with measures for each electrode pair at all frequency bands and across the overall spectrum. The intensity of each cell represents the covariance between activity in the corresponding electrode pairs at the corresponding frequency band. Visualisation suggests differences in network activities; comparison of first principal components indicated a statistically significant difference between groups (p < 0.0001, Mann-Whitney U test), indicating that there are differences in network architecture between the genetic subtypes. The MECP2 group primarily shows a pattern of low covariance in networks involving left-sided occipital and temporal electrode pairs, as well as reduced involvement of right-sided occipito-temporal pairs. The CDKL5 network architecture is visually different, primarily distinguished by very low covariance cross all pairs in delta band, including cross-frequency, indicating abnormalities in network function within this frequency range, as well as very low network involvement of right occipital and parietal regions. b Subplots of overall covariance matrices in A, showing only covariance between electrode pairs over the whole power spectrum. Each row and each column represents an electrode pair as labelled. Closer examination of covariance within the overall spectrum suggests that differences seen across the whole matrix are still evident within the overall spectrum alone