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. 2018 Oct 19;18:333. doi: 10.1186/s12887-018-1304-7

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — Spectral power profiles of phenotypic variants of Rett Syndrome. All subplots depicting a statistical comparison significant at a p value of < 0.05 are marked with an asterisk (*). a Overall power spectra between 1 Hz and 40 Hz for Classic (n = 26, blue), Hanefeld (n = 4, red) and PSV (n = 5, green) phenotypes. The Classic group shows a tendency towards higher power in the higher range of frequencies, though the differences in overall spectra between phenotypic groups were not statistically significant (Kruskal-Wallis H test; p > 0.05). b Head plots demonstrate the spatial distribution of overall spectral power in Classic (left), Hanefeld (middle) and PSV (right) phenotypes. Dots represent electrode locations. Colour maps show relative power of the overall spectrum interpolated between electrodes. Colour maps were calculated using the maximum (red) and minimum (blue) across the entire population and applied to all groups, allowing direct comparison of power distribution between groups. The differences in power at each individual electrode were not statistically significant (Kruskal-Wallis H test; p > 0.05). c Profile of hemispheric asymmetry at each frequency band by electrode location for Classic (left), Hanefeld (middle) and PSV (right) phenotypes. Each column represents a scalp location. Each row represents a frequency band. Cell colour is determined by the asymmetry of the corresponding band at the corresponding location, calculated by subtracting the power in that band at that location on one side from the other. Red indicates greater power in the left hemisphere, blue indicates greater power in the right hemisphere, and intensity indicates the magnitude of the asymmetry. The Classic group does not demonstrate an obvious pattern of hemispheric asymmetry, while the PSV and, to a greater extent, the Hanefeld group demonstrate a tendency towards asymmetry favouring the left hemisphere, though these differences are not statistically significant when all groups are compared (Kruskal-Wallis H test; p > 0.05)