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. 2018 Oct 20;15:292. doi: 10.1186/s12974-018-1327-x

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© The Author(s). 2018

Open AccessThis article is distributed under the terms of the Creative Commons Attribution 4.0 International License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted use, distribution, and reproduction in any medium, provided you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The Creative Commons Public Domain Dedication waiver (http://creativecommons.org/publicdomain/zero/1.0/) applies to the data made available in this article, unless otherwise stated.

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Fig. 3 — SIRT1 modulated the NALP1 expression following bortezomib treatment. a The photographs show double staining between SIRT1 (red) with NALP1 (green) in spinal dorsal horn on day 10 following bortezomib treatment. n = 4 in each group; scale bar, 50 μm. Intrathecal injection of resveratrol (250 μg/10 μl for 10 days) inhibited the upregulation of NALP1 mRNA (b) and protein (c) level in dorsal horn of rats on day 10 following BTZ treatment. n = 6 in each group, **P < 0.01 versus the vehicle group, ^##P < 0.01 versus the corresponding BTZ group. d Intrathecal injection of SIRT siRNA increased the NALP1 expression in normal rats. n = 6 in each group, **P < 0.01 versus the control group