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. Author manuscript; available in PMC: 2019 Dec 28.
Published in final edited form as: Cancer Lett. 2018 Sep 19;439:56–65. doi: 10.1016/j.canlet.2018.09.024

Figure 6.

Figure 6.

In vivo efficacy of a combination of BKM120 and volasertib (BI6727). A, relative tumor growth (±SEM) of T4888M allografts treated with vehicle, single drugs, and combination. Values are normalized to the tumor volume at the beginning of treatment. P<0.003 from day 13 onwards when comparing BKM120 to the combined treatment. B, tumor weights at endpoint. C, Average mouse weight at the beginning and at day 17 of treatment. D,E immunohistochemical detection of proliferation (D) and apoptosis (E) in sections from tumors collected at endpoint. F, quantification of Ki67 and TUNEL positive cells.