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. Author manuscript; available in PMC: 2018 Nov 10.
Published in final edited form as: Oncogene. 2018 May 10;37(33):4534–4545. doi: 10.1038/s41388-018-0282-4

Figure 3. Targeting HERV-K transactivation significantly reduces KSHV-induced primary endothelial cell invasiveness.

Figure 3

(A-C) HUVEC cells were incubated with purified KSHV (MOI~10) for 2h, then transfected with non-target control siRNA (n-siRNA) or HERV-K env-siRNA for additional 48 h. The transwell assays were performed to determine relative invasiveness as described in the Methods. (D) The concentrations of VEGF in culture supernatants were determined using ELISA. (E) The gene transcripts were quantified by using qRT-PCR. Error bars represent the S.D. from 3 independent experiments. ** = p<0.01.