Table 3.
Outcomes analysis based on duration of early antibiotic exposure
| No antibiotics (n=1004) | ≤48h of antibiotics (n=1366) | 3-7d of antibiotics (n=2580) | p | |
|---|---|---|---|---|
| BPD or death prior to 36 wk PMA | 312 (31.1%) | 529 (38.7%) | 1110 (43.0%) | <0.001 |
| Adjusted OR [95%CI]1 | Reference | 1.19 [0.88,1.62] | 0.82 [0.65,1.04] | |
| BPD among survivors to 36 wk PMA2 | 283 (29%) | 368 (30.5%) | 968 (39.7%) | <0.001 |
| Adjusted OR [95% CI]1 | Reference | 1.00 [0.71,1.42] | 0.78 [0.62,0.97] | |
| Death prior to 36 wk PMA | 29 (2.9%) | 160 (11.7%) | 142 (5.5%) | <0.001 |
| Adjusted OR [95%CI]1 | Reference | 6.01 [3.11,11.55] | 1.65 [0.82,3.33] |
1
Adjusted for gestational age, birthweight, sex, race/ethnicity, prenatal steroids, chorioamnionitis, gestational hypertension or pre/eclampsia, gestational diabetes, mode of delivery, small for gestational age, and exclusive human milk feeding, treatment with caffeine, surfactant, mechanical ventilation on the first day of life, and the total duration (days) of mechanical ventilation during the first week of life
2
Denominators for survivors to 36 wk PMA: 975 (no antibiotics); 1205 (≤48h antibiotics); 2437 (3-7d antibiotics)
BPD (bronchopulmonary dysplasia); wk (weeks); h (hours); d (days); OR (odds ratio); CI (confidence interval); PMA (postmenstrual age)