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. Author manuscript; available in PMC: 2019 Nov 1.

Published in final edited form as: Hepatology. 2018 Jul 10;68(5):1890–1904. doi: 10.1002/hep.30051

3-83 Ig transgenic mice with B cells specific for irrelevant antigen (3-83) develop murine BA. Newborn wildtype (WT) or 3-83 Ig knock-in mice (3-83) were injected with BSS (control) or RRV (BA) and analyses performed at 14 days of age. A. Percent incidence of jaundice in non-fur bearing regions. B. Serum direct bilirubin and alkaline phosphatase levels. C. Representative H&E of intrahepatic and extrahepatic bile ducts (arrows) showing bile duct inflammation and injury with disruption of lining of ducts (*) and summary of liver injury scores (range of possible scores for an individual injury marker given in parentheses). D. Absolute number of liver immune cells (gated on FSC/SSC, CD45⁺ cells). ***p < 0.0005; **p < 0.005; *p < 0.05

3-83 Ig transgenic mice with B cells specific for irrelevant antigen (3-83) develop murine BA. Newborn wildtype (WT) or 3-83 Ig knock-in mice (3-83) were injected with BSS (control) or RRV (BA) and analyses performed at 14 days of age. A. Percent incidence of jaundice in non-fur bearing regions. B. Serum direct bilirubin and alkaline phosphatase levels. C. Representative H&E of intrahepatic and extrahepatic bile ducts (arrows) showing bile duct inflammation and injury with disruption of lining of ducts (*) and summary of liver injury scores (range of possible scores for an individual injury marker given in parentheses). D. Absolute number of liver immune cells (gated on FSC/SSC, CD45⁺ cells). ***p < 0.0005; **p < 0.005; *p < 0.05