Table 2.

Representative genotoxicity assays

	In vitro	In vivo
Gene mutation assays	Bacterial reverse mutation assay (Ames test) (TG471)	Transgenic rodent gene mutation assay (TG488)
	Mammalian gene mutation assay (TG476; 490)
Cytogenetic assays	Chromosome aberration assay (TG473)	Chromosome aberration assay (TG475)
	Micronucleus assay (TG487)	Micronucleus assay (TG474)

TG numbers represent numbers of test guidelines established by OECD (https://www.oecd-ilibrary.org).

Although it is neither gene mutation assay nor cytogenetic assay, OECD test guideline (TG489) has been established for in vivo comet assay, which detects DNA strand breaks.