Table 2.
Smoking differentially expressed genes in adipose tissue (42 smoking-DES)
| ID | CHR | Name | Coef. | S.E. | P value | cis eQTLs |
|---|---|---|---|---|---|---|
| ENSG00000140465.7 | 15 | CYP1A1 | 1.899 | 0.103 | 5.37 × 10−51 | rs35213055; 1.53 × 10−6 |
| ENSG00000138061.7 | 2 | CYP1B1 | 1.373 | 0.131 | 2.83 × 10−21 | |
| ENSG00000144331.14 | 2 | ZNF385B | − 1.257 | 0.134 | 1.53 × 10−18 | rs9288034; 8.33 × 10−5 |
| ENSG00000179151.6 | 15 | EDC3 | 1.167 | 0.129 | 3.10 × 10−17 | |
| ENSG00000063438.12 | 5 | AHRR | 1.059 | 0.149 | 6.03 × 10−12 | |
| ENSG00000175267.8 | 16 | VWA3A | 0.932 | 0.139 | 2.18 × 10−10 | |
| ENSG00000170381.7 | 7 | SEMA3E | − 0.821 | 0.137 | 8.35 × 10−9 | chr7:83264879;1.22 × 10−10 |
| ENSG00000170891.6 | 4 | CYTL1 | 0.807 | 0.142 | 2.82 × 10−8 | |
| ENSG00000187486.5 | 11 | KCNJ11 | − 0.859 | 0.148 | 3.27 × 10−8 | |
| ENSG00000168280.11 | 2 | KIF5C | − 0.813 | 0.145 | 4.74 × 10−8 | |
| ENSG00000006016.5 | 19 | CRLF1 | 0.769 | 0.146 | 2.53 × 10−7 | chr19:18717389; 2.63 × 10−6 |
| ENSG00000127533.2 | 19 | F2RL3 | 0.782 | 0.147 | 2.89 × 10−7 | |
| ENSG00000149294.11 | 11 | NCAM1 | − 0.715 | 0.135 | 3.03 × 10−7 | rs17510563; 2.01 × 10−7 |
| ENSG00000120693.9 | 13 | SMAD9 | − 0.733 | 0.140 | 4.76 × 10−7 | |
| ENSG00000169116.7 | 4 | PARM1 | − 0.686 | 0.133 | 6.76 × 10−7 | |
| ENSG00000154330.6 | 9 | PGM5 | − 0.716 | 0.147 | 1.72 × 10−6 | |
| ENSG00000162430.12 | 1 | SEPN1 | − 0.663 | 0.137 | 1.82 × 10−6 | |
| ENSG00000154721.9 | 21 | JAM2 | − 0.667 | 0.136 | 2.23 × 10−6 | |
| ENSG00000177303.4 | 17 | CASKIN2 | − 0.669 | 0.140 | 2.90 × 10−6 | |
| ENSG00000157404.10 | 4 | KIT | 0.708 | 0.150 | 3.31 × 10−6 | |
| ENSG00000161544.4 | 17 | CYGB | 0.621 | 0.131 | 3.42 × 10−6 | |
| ENSG00000154065.9 | 18 | ANKRD29 | − 0.684 | 0.144 | 3.49 × 10−6 | |
| ENSG00000176907.3 | 8 | C8orf4 | − 0.714 | 0.151 | 3.56 × 10−6 | |
| ENSG00000168032.4 | 3 | ENTPD3 | − 0.674 | 0.140 | 3.86 × 10−6 | rs34158576; 7.60 × 10−6 |
| ENSG00000162367.6 | 1 | TAL1 | − 0.665 | 0.142 | 4.17 × 10−6 | |
| ENSG00000180785.8 | 11 | OR51E1 | − 0.655 | 0.142 | 6.82 × 10−6 | rs11033126; 3.78 × 10−10 |
| ENSG00000164010.9 | 1 | ERMAP | − 0.690 | 0.154 | 9.50 × 10−6 | |
| ENSG00000068078.12 | 4 | FGFR3 | − 0.643 | 0.143 | 9.68 × 10−6 | rs744658; 9.68 × 10−8 |
| ENSG00000246223.4 | 14 | C14orf64 | − 0.633 | 0.142 | 1.44 × 10−5 | rs75700090; 2.00 × 10−5 |
| ENSG00000145506.9 | 5 | NKD2 | 0.616 | 0.140 | 1.46 × 10−5 | |
| ENSG00000161649.7 | 17 | CD300LG | − 0.648 | 0.147 | 1.48 × 10−5 | |
| ENSG00000163873.5 | 1 | GRIK3 | − 0.643 | 0.146 | 1.50 × 10−5 | |
| ENSG00000053747.9 | 18 | LAMA3 | − 0.652 | 0.148 | 1.57 × 10−5 | |
| ENSG00000183733.6 | 2 | FIGLA | 0.406 | 0.093 | 1.57 × 10−5 | |
| ENSG00000164736.5 | 8 | SOX17 | − 0.629 | 0.144 | 1.64 × 10−5 | |
| ENSG00000106078.12 | 7 | COBL | − 0.680 | 0.155 | 1.65 × 10−5 | |
| ENSG00000120156.14 | 9 | TEK | − 0.610 | 0.140 | 1.67 × 10−5 | |
| ENSG00000178726.5 | 20 | THBD | − 0.612 | 0.141 | 2.00 × 10−5 | |
| ENSG00000177675.4 | 12 | CD163L1 | 0.635 | 0.148 | 2.40 × 10−5 | |
| ENSG00000136828.13 | 9 | RALPGS1 | − 0.646 | 0.151 | 2.60 × 10−5 | |
| ENSG00000135914.4 | 2 | HTR2B | 0.613 | 0.144 | 2.82 × 10−5 | |
| ENSG00000090530.5 | 3 | LEPREL1 | − 0.617 | 0.145 | 2.86 × 10−5 | rs6768989; 1.10 × 10−9 |
ID, Ensemble ID; CHR, chromosome; Coef., regression coefficients from the linear mixed effect model, positive values reflect higher expression in current smokers and negative values represent lower expression in current smokers; eQTL, expression quantitative trait locus