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Antiviral RNAi in mammals. During RNA virus infection of mammalian host cells, dsRNA replicative intermediates are processed into viral siRNAs (vsiRNAs) by Dicer, which is the step targeted for the suppression by several dsRNA-binding VSRs. In the absence of VSR expression, specific degradation of the cognate viral RNAs occurs and requires the vsiRNAs and AGO2, both of which are assembled into antiviral RISC in the infected cells.
