Skip to main content
. Author manuscript; available in PMC: 2019 Oct 1.
Published in final edited form as: Curr Opin Immunol. 2018 Jul 17;54:109–114. doi: 10.1016/j.coi.2018.06.010

Table 2.

Properties of the mammalian viral suppressors of RNAi (V SR) verified during authentic infection of mammalian cells

Virus VSR Protein size Protein structure dsRNA binding VSR mechanism IFN-I antagonist Virulence factor in vivo Replication defect of VSR mutants Rescue of VSR mutants in RNAi-defective cells
Nodamura Virus B2 137 amino acids, 15 kDa Dimeric, helical bundle structure Yes Suppress Dicer processing nd (not determined) Yes Yes Yes
Influenza A Virus NS1 230 amino acids, 26 kDa Dimeric, helical bundle structure Yes Suppress Dicer processing Strong activity Yes Yes Yes
Human Enterovirus 71 3A 86 amino acids, 9.6 kDa nd Yes Suppress Dicer processing Weak activity Yes Yes Yes