Figure 4.

TAUR ameliorates MI-induced cardiac dysfunction. (A,B) Ejection fraction (EF%) and fractional shortening (FS%) were determined by echocardiography 7 days after MI. (C) Measurement of LV cavity size was performed at the papillary muscle level 7 days after MI. (D) Representative photomicrographs of Picrosirius red staining at the papillary muscle level 7 days after MI are shown. (E) Quantification of scar size at the papillary muscle level was performed 7 days after MI. Data are presented as mean ± SD. n=5–6 per group. *, P<0.05 versus sham group; ^†, P<0.05 versus vehicle-MI group. MI, myocardial infarction; WT, wild type; TAUR, tauroursodeoxycholic acid.