Figure 5.

TAUR reduces MI-induced cardiomyocyte death in mice. Cell death in non-infarcted areas was determined by PI, and Hoechst staining was used for nuclear counterstaining. (A) Representative microphotographs of Hoechst staining (blue) and PI staining (red) on sections of non-infarcted myocardia prepared from vehicle-MI and TAUR-MI mice are shown. Arrows indicate Hoechst/PI positive cells. (B) Quantification of (A) was performed as described in “Methods” section. n=6 per group. (C) Analysis of mortality rates of vehicle-MI and TAUR-MI mice 7 days after MI. ^†, P<0.05 versus vehicle-MI mice. MI, myocardial infarction; PI, propidium iodide; TAUR, tauroursodeoxycholic acid.