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. 2018 Oct 22;10(4):30. doi: 10.1038/s41368-018-0033-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — Forty-eight hours after HSC-4 cells were seeded into a 12-well plate, the medium was replaced with medium containing FR180204 (50 μmol•L⁻¹). After 48 h, the medium was changed again to a medium containing FR180204 and incubated for another 48 h. Changes in the structure of squamous epithelial cancer cell layers following ERK inhibitor treatment. Suppression of the invasive capacity of HSC-4 cells was observed, with thinning of the layered structure of cancer cells compared to control cells, following the administration of the ERK inhibitor FR180204 (scale bar: 50 μm)