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. 2018 Oct 22;10(4):30. doi: 10.1038/s41368-018-0033-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 5 — The effect of ezrin small interfering RNA (siRNA) and administration of ERK inhibitor (FR180204) on 3D-cultured HSC-3 and HSC-4 cells. a Expression of ezrin and p-cortactin (Tyr421) after siRNA treatment. Suppression of ezrin expression was observed in siEzrin cells in 3D-cultured HSC-3 and HSC-4 cell lines, but no difference was observed in the expression of p-cortactin (Tyr421) (n = 3). b Expression of p-ERK and cortactin and p-cortactin (Tyr421) following treatment with ERK inhibitor. In both 3D-cultured HSC-3 and HSC-4 cell lines, p-ERK expression was suppressed in FR cells, but no difference was observed in the expression of t-ERK. In addition, in FR cells, although no difference was observed in the expression of cortactin, p-cortactin (Tyr421) expression was significantly suppressed (n = 3)