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. 2018 Oct 22;10(4):30. doi: 10.1038/s41368-018-0033-y

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© The Author(s) 2018

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 7 — Immunofluorescent staining of 2D and 3D-cultured tongue cell lines. a Immunofluorescent staining was carried out on HSC-3 cells after 2D culture for 2 days on a glass coverslip. The colocalization of F-actin and cortactin, known as invadopodia, was observed in the form of punctae in the cell cytoplasm (scale bar: 10 μm). b, c Immunofluorescent staining of 3D-cultured tongue cell lines. Cell projections formed in the control cells in both HSC-3 (b) and HSC-4 cell lines (c); F-actin and cortactin colocalized in the cell margin. The formation of cell projections was markedly decreased in FR cells (scale bar: 50 μm)