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. 2018 Oct 15;6:124. doi: 10.3389/fcell.2018.00124

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Copyright © 2018 de Pater and Trompouki.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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(A) Overview of definitive hematopoietic sites in the developing embryo where HSPCs are born from hemogenic endothelial cells of the dorsal aorta (DA). HSPCs are amplified in the caudal hematopoietic tissue (CHT) and migrate to the kidney and thymus. (B) Endothelial-to-hematopoietic transition (EHT) event imaged in a Tg(fli:GFP) embryo between 32 and 40 hpf. (C) CHT region in Tg(flt:RFP)/Tg(CD41:GFP) embryo at 56 hpf indicating erythroid myeloid progenitors (EMP) in green and definitive HSPCs in yellow as they originate from the artery and retain RFP at this timepoint. (D) Sagittal section through an adult zebrafish where the head kidney is indicated with enlargement showing the hematopoietic cells in between the kidney tubules.