Table 1.
The contribution of NOVO and RR in the transport of CAP across the jejunum, ileum, and colon.
| Compounds | Papp (×10-6, cm⋅s-1; fold-inhibition factor) |
|||
|---|---|---|---|---|
| Jejunum | Ileum | Colon | ||
| CAP | 3.14 ± 0.24 (1.00) | 7.37 ± 0.99 (1.00) | 19.97 ± 3.09 (1.00) | |
| +5 μM NOVO | 1.96 ± 0.25∗ (1.60) | 3.40 ± 0.76∗ (2.17) | 8.28 ± 2.55∗ (2.41) | |
| +10 μM NOVO | 1.36 ± 0.47∗ (2.31) | 2.17 ± 0.58∗ (3.40) | 6.05 ± 1.85∗ (3.30) | |
| +25 μM NOVO | 1.60 ± 0.38∗ (1.97) | 4.02 ± 0.42∗ (1.83) | 5.65 ± 2.04∗ (3.54) | |
| +50 μM NOVO | 2.11 ± 0.04∗ (1.49) | 5.23 ± 0.25 (1.41) | 9.79 ± 2.20∗ (2.04) | |
| +10 μM RR | 2.54 ± 0.40 (1.23) | 5.06 ± 0.57∗ (1.46) | 12.18 ± 2.90∗ (1.64) | |
Each compound was consisted of 100 μM CAP in the absence or presence of the indicated concentrations of NOVO or RR. Each value represents mean ± SD (n = 5). ∗p < 0.05, versus the group treated with CAP in the absence of NOVO or RR. The fold-inhibition factor of NOVO or RR (values given in parentheses) was calculated by dividing the Papp with CAP in the absence of NOVO or RR by that obtained in the presence of NOVO or RR.