Table 4.
Pharmacokinetic parameters of CAP after the oral administration of CAP (10 mg⋅kg-1) in combination with NOVO (12.5–100 mg⋅kg-1) in rats.
| Dosing Group | N | Cmax (ng⋅mL-1) | Tmax (min) | AUC0-720 min(ng⋅min⋅mL-1) |
|---|---|---|---|---|
| Blank | 5 | 52.157 ± 8.920 | 234 ± 25.100 | 13793.660 ± 1862.059 |
| NOVO 12.5 mg⋅kg-1 | 5 | 32.534 ± 2.248 | 222 ± 26.832 | 10203.630 ± 432.204 |
| NOVO 25 mg⋅kg-1 | 5 | 29.874 ± 3.355∗ | 234 ± 25.100 | 9217.946 ± 326.929∗ |
| NOVO 50 mg⋅kg-1 | 5 | 25.082 ± 0.957∗ | 264 ± 13.416 | 7874.992 ± 629.840∗ |
| NOVO 100 mg⋅kg-1 | 5 | 43.137 ± 8.829 | 224 ± 25.100 | 14547.74 ± 1084.295 |
All data are represented as the mean ± SD values from six independent experiments. ∗p < 0.05, statistic versus Blank.