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. 2018 Oct 15;9:1461. doi: 10.3389/fphys.2018.01461

FIGURE 2.

FIGURE 2

Responses of RSNA, MAP, and HR evoked by stimulation of TRPV1 and TRPA1 receptors with arterial injection of capsaicin and AITC. (A) Three dosages of capsaicin evoked increases in RSNA and MAP in a dose-dependent manner in control rats (n = 10) and occluded rats (n = 8). The effects were greater in occluded rats. As PTX was given previously in occluded rats (n = 8), amplified RSNA and MAP responses were attenuated. ∗P < 0.05, compared with control rats and †P < 0.05, compared with occluded rats without PTX. (B) In the similar way, the RSNA and MAP were increased after injection of three dosages of AITC in control rats (n = 8), occluded rats (n = 6), and occluded rats with PTX treatment (n = 8). The responses were enhanced in occluded rats and PTX can attenuate increases of RSNA and MAP responses. ∗P < 0.05, compared with control rats and †P < 0.05, compared with occluded rats without PTX.