| Genes | Family/functions | References |
|---|---|---|
| (B) CHARACTERISTICS OF SELECTED GENES ACCORDING TO THEIR FAMILY AND FUNCTIONS | ||
| HLA-DRA | Alpha chain of the heterodimer MHC class II (α, β)/cell-surface glycoproteins/APCs | (8, 23) |
| HLA-DRB1 | Beta chain of the heterodimer MHC class II (α, β)/cell-surface glycoproteins/APCs | (8, 18, 23) |
| IFN AND ISGs | ||
| IRF1 | Type I, II IFN/interferon regulatory transcription factor family/regulating apoptosis | (24) |
| IFI44 | Type I, IFN/viral response/antiproliferative/associated with hepatitis C virus infection | (25–27) |
| HSH2D | Type I, IFN/intracellular protein tyrosine kinase signaling, regulation of cytokine signaling and cytoskeletal reorganization | (28, 29) |
| MX1 | Type I, III IFN/GTPases/viral response/programmed cell death regulation of apoptosis | (30–32) |
| OAS2 | Type I, III IFN/2–5 A synthetase family/viral response/degradation of viral RNA | (33, 34) |
| Toll-like Receptor and Related | ||
| TLR2 | Cell-surface protein/pathogen recognition/innate immunity/apoptosis | (35–38) |
| TLR3 | Cell-surface protein/recognizes viral dsRNA/innate immunity/apoptosis, NF-κB activation/production of type I IFN | (35, 38, 39) |
| MYD88 | Cytosolic adapter protein/innate and adaptive immune response/interleukin-1 and Toll-like receptor signaling pathways. | (38) |
| TNF Superfamily | ||
| CD40 | TNF receptor superfamily member 5/adaptive immune response/TNFR/membrane receptor/regulation of immune reactions | (40, 41) |
| TRAF2 | Adaptor molecule/p38, Akt and JNK activation | (42, 43) |
| TRADD | Adaptor molecule/apoptosis/cell death signaling and NF-κB activation | (44) |
| Enzymes | ||
| RIPK2 | NF-κB activation/apoptosis/innate and adaptive immune pathways | (45, 46) |
| MAPK | ||
| MAPKAPK2 | Kinases/MAPKs subtype p38/regulation of pro-inflammatory cytokines | (47, 48) |
| MAPK8 | Kinases/stress-responsive c-Jun N-terminal kinase (JNK)/proliferation, differentiation, transcription regulation | (49) |
| STAT | ||
| STAT1 | Activators of transcription/cell viability/response to IFN | (50) |
| STAT2 | Activators of transcription/cell viability/response to IFN | (50) |
| STAT3 | Activators of transcription/cell viability/response to IFN | (50) |
| Chemokines/Cytokines | ||
| CCL22 | Ligand of chemokine receptor CCR4/Th2 cell migration | (51) |
| IL15 | Type-I cytokine family/regulates T and natural killer cell activation and proliferation/activation of JAK kinases/not secreted/monocytes/macrophages | (52) |
| Complement AND CRP | ||
| C2 | Extracellular region/classical pathway of complement activation/innate immunity | (53) |
| CFB | Extracellular region/alternative pathway of complement activation/innate immunity | (54) |
The selected genes showing high correlations with R > 0.8 are described according to their family and their function in various cells.