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A concept of targeted drug delivery to glioblastoma across the BBB. Nanoparticle (N) combined with a monoclonal antibody (MAb) for receptor (R) crosses the blood brain barrier (BBB) into brain by Trojan horse approach. N with a ligand targeting BBB traverses the BBB by receptor-mediated transcytosis. Ligand ▸ docks on a cancer cell receptor N⊳ and delivers anticancer payload to the cancer cell in glioblastoma.
