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. 2018 Oct 15;9:2360. doi: 10.3389/fimmu.2018.02360

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Copyright © 2018 Pesce, Squillario, Greppi, Loiacono, Moretta, Moretta, Sivori, Castagnola, Barla, Candiani and Marcenaro.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Heatmap representing the unsupervised hierarchical clustering analysis of CD56^bright/CD16⁻ and CD56^dim/CD16⁺ NK cells miRNAs signature obtained with the univariate analysis. Heatmap of 37 miRNAs signature identified by the human miRNA microarray kit v19.0. Dendrograms indicate the results of the bi-clustering analysis. Table at the bottom of the figure helps with the translation between centered log₂ data and fold-change values, and also introduces the heat map color scheme used. Colored boxes indicate 7 of the most regulated miRNAs. Color legend: the most up-regulated miRNAs on CD56^bright/CD16⁻ NK cells are indicated in light blue and the most up-regulated miRNAs on CD56^dim/CD16⁺ NK cells are indicated in purple.