Table 1.
Absolute number of lymphocyte subpopulations in peripheral blood in the unPAD patients.
| Population | N = | Reference range × 10e9/la | Median (IQR) × 10e9/l | Decreased (n) |
|---|---|---|---|---|
| Helper T-lymphocytes (CD3+CD4+) | 75 | 0.5–2.0 | 0.9 (0.7–1.2) | 4 |
| T-lymphocytes (CD3+) | 75 | 0.78–3.0 | 1.4 (1.2–2.0) | 4 |
| Cytotoxic T-lymphocytes (CD3+CD8+) | 75 | 0.2–1.2 | 0.5 (0.3–0.7) | 3 |
| NK-cells (CD3+CD16+and/orCD56+) | 74 | 0.10–1.2 | 0.2 (0.1–0.3) | 4 |
| B-lymphocytes (CD19+) | 75 | 0.064–0.82 | 0.20 (0.11–0.30) | 3 |
| IgM only memory B-lymphocytes (CD19+CD27+IgM+IgD−) | 67 | 0.0011–0.015 | 0.0034 (0.0013–0.0066) | 11 |
| Switched memory B-lymphocytes (CD19+CD27+IgM−IgD−) | 67 | 0.0045–0.13 | 0.021 (0.011–0.044) | 6 |
| CD21low B cells (CD19+CD21lowCD38low) | 67 | 0.0017–0.049 | 0.0058 (0.003–0.010) | 7b |
| Naïve B-lymphocytes (CD19+CD27−IgM+IgD+) | 67 | 0.028–0.55 | 0.09 (0.046–0.16) | 10 |
| Transitional B cells (CD19+CD38++IgM++) | 67 | 0.0006–0.10 | 0.0082 (0.0031–0.016) | 7 |
a
From Schatorjé et al. (15).
b
Increased CD21low cell population in 2 patients.