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. 2018 Oct 15;12:367. doi: 10.3389/fncel.2018.00367

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Copyright © 2018 Almeida.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Regulation of CNS myelin targeting. (A) myelin is targeted in a short period in the life of an oligodendrocyte (OL): a selection stage during differentiation and a refinement stage after differentiation. (B) Biophysical properties of diameter and/or curvature determine the permissiveness of a target for myelination. (C) Curvature or length-sensing proteins in oligodendrocyte processes may sense appropriately sized targets. (D) Attractive and repulsive cell-adhesion molecules on prospective targets regulating CNS myelination. (E) Similar to synapse formation, the temporal dynamics of key signaling pathways (e.g., Eph) may determine the fate of OPC processes during myelin target selection.