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Incomplete germinal center disruption after alemtuzumab treatment in the lymph node and spleen. (A) Significantly higher frequency of CD3 T cells were found in the lymph nodes compared to other immune compartments at POD 5 and POD 14 (Gray area = non-depleted control, Red line = alemtuzumab treated). (B) Immunohistochemistry demonstrated cell components of germinal center. T, B, Ki67 and PNA staining confirmed germinal center (GC) response at 24 h after alemtuzumab treatment.
