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Functions and mechanisms of lncRNA. LncRNA can guide transcription factors to specific genomic locations for the regulation of gene expression (upper-left). LncRNA works as a scaffold to facilitate the assembling of chromatin remodeling complexes (upper-right). LncRNA can also serve as a sponge to titrate miRNAs out from their mRNA targets (lower-left). LncRNA can bind to transcription factors or other proteins as a decoy and sequester them away from chromatin (lower-right).
