FIGURE 3.
RMD+IBET151 with vaccination provides enhanced protection against L. monocytogenes. C57BL/6 mice were either (A and B) primed with Ad26 (109 vp) and boosted with Ad5 (109 vp) or (C) vaccinated s.c. with OVA protein adjuvanted with CpG in combination with RMD, IBET151, RMD+IBET151, or PBS/DMSO. (B and C) L. monocytogenes titers in the spleen 2 d after challenge. Each dot represents an individual mouse. n = 4–10 per group per experiment. Data are presented as means ± SEM. *p < 0.05, ***p < 0.001, Student t test.