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. 2018 Sep 24;201(9):2744–2752. doi: 10.4049/jimmunol.1800885

FIGURE 4.

FIGURE 4.

Differential expression of apoptosis- and chromatin-related genes in CD8+ T cells following RMD+IBET151 treatment. (A and C) Experimental outline prior to Ag-specific CD8+ T cell sorting and RNA-Seq. (B and D) Correlation graph and volcano plot of differentially expressed genes between RMD+IBET151–treated and PBS/DMSO–treated SIINFEKL+CD8+ T cells. (E) Differentially expressed genes related to apoptosis. (F) Differentially enriched pathways following RMD+IBET151 treatment on adenoviral and protein vaccination related to chromatin modification and binding. n = 5 per group, C57BL/6 mice.