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. 2018 Oct 15;9:2420. doi: 10.3389/fmicb.2018.02420

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Copyright © 2018 Ledder, Kampoo, Teanpaisan and McBain.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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Salivary DNA profiles from primary subject cavity-free and S-ECC children (age <6 years) or caries (age >6 years), and caregivers and their siblings. Open circles, cavity–free; closed circles, S-ECC. Symbol color: Family 1, black; Family 2, purple; Family 3, blue; Family 4, orange; Family 5, gray. Contour lines on the MDS plot superimpose 50% resemblance levels derived from cluster analysis (not shown). Profiles could be differentiated on the basis of family (p < 0.05). S-ECC and cavity-free families could not be differentiated (p = 3.18). Carious sites and cavity-free sites could not be differentiated (p = 8.1).