Table 1.
Sociodemographic characteristics, risk factors, and polymorphisms GSTT1, GSTM1, GSTP1 A313G in patients with colorectal cancer and controls n (%)
| Variables | Case (n = 232) | Control (n = 738) | OR1 (95%CI) | |
| Gender | ||||
| Male | 112 (48) | 370 (50) | 1.00 | |
| Female | 120 (52) | 368 (50) | 2.91 (1.94-4.37)a | |
| Age [yr (mean) ± SD] | (62) ± 12 | (48) ± 12 | ||
| < 62 | 112 (49) | 621 (84) | 1.00 | |
| ≥ 62 | 120 (51) | 117 (16) | 8.79 (5.90-13.09)a | |
| Smoking Habit | ||||
| Non-smoker | 130 (56) | 465 (63) | 1.00 | |
| Smoker | 102 (44) | 273 (37) | 1.45 (0.98-2.14) | |
| Alcohol Consumption | ||||
| Non-drinker | 132 (57) | 395 (54) | 1.00 | |
| Drinker | 100 (43) | 343 (46) | 1.28 (0.85-1.91) | |
| GSTP1 | ||||
| Codominant | A/A | 227 (43.7) | 107 (46.1) | 1.00 |
| A/G | 224 (43.2) | 102 (44) | 1.06 (0.73-1.54) | |
| G/G | 68 (13.1) | 23 (9.9) | 0.88 (0.48-1.59) | |
| Dominant | A/A | 227 (43.7) | 107 (46.1) | 1.00 |
| A/G-G/G | 292 (56.3) | 125 (53.9) | 1.02 (0.71-1.45) | |
| Recessive | A/A-A/G | 451 (86.9) | 209 (90.1) | 1 |
| G/G | 68 (13.1) | 23 (9.9) | 0.85 (0.48-1.50) | |
| Overdominant | A/A-G/G | 295 (56.8) | 130 (56) | 1.00 |
| A/G | 224 (43.2) | 102 (44) | 1.09 (0.76-1.55) | |
| Additive | - | - | 0.97 (0.75-1.27) | |
| GSTT1 | ||||
| +/+ | 573 (77.6) | 192 (82.8) | 1.00 | |
| 0/0 | 165 (22.4) | 40 (17.2) | 0.65 (0.43-0.98)a | |
| GSTM1 | ||||
| +/+ | 385 (52.2) | 100 (43.1) | 1.00 | |
| 0/0 | 353 (47.8) | 132 (56.9) | 1.45 (1.06-2.00)a |
1
OR adjusted for age, gender, and alcohol and smoking habits and polymorphisms;
a
P < 0.05 vs control. OR: Odds ratio.