Table 2.
Interaction between polymorphisms in the genes GSTP1, GSTT1, and GSTM1 and smoking or alcohol habits on the risk of sporadic colorectal cancer
|
Tobacco consumption |
Alcohol consumption |
|||||||||||
|
Non-smoker |
Smoker |
Non-smoker |
Smoker |
|||||||||
| Case | Control | OR1 (95%CI) | Case | Control | OR1 (95%CI) | Case | Control | OR1 (95%CI) | Case | Control | OR1 (95%CI) | |
| GSTP1 | ||||||||||||
| A/A | 50 | 136 | 1.00 | 57 | 91 | 2.33 (1.34-4.05)a | 59 | 116 | 1.00 | 48 | 111 | 1.31 (0.74-2.31) |
| A/G-G/G | 80 | 177 | 1.40 (0.87-2.27) | 45 | 115 | 1.59 (0.91-2.77) | 73 | 147 | 1.12 (0.69-1.81) | 52 | 145 | 1.19 (0.70-2.04) |
| GSTT1 | ||||||||||||
| +/+ | 110 | 362 | 1.00 | 82 | 211 | 1.42 (0.98-2.08) | 108 | 300 | 1.00 | 84 | 273 | 0.76 (0.52-1.12) |
| 0/0 | 20 | 103 | 0.60 (0.34-1.04) | 20 | 62 | 1.03 (0.57-1.88) | 24 | 95 | 0.63 (0.37-1.07) | 16 | 70 | 0.53 (0.28-1.01) |
| GSTM1 | ||||||||||||
| +/+ | 52 | 231 | 1.00 | 48 | 154 | 1.40 (0.86-2.28) | 56 | 206 | 1.00 | 44 | 179 | 0.76 (0.46-1.26) |
| 0/0 | 78 | 234 | 1.38 (0.90-2.10) | 54 | 119 | 2.19 (1.34-3.57) | 76 | 189 | 1.42 (0.93-2.18) | 56 | 164 | 1.14 (0.72-1.82) |
1
OR adjusted for age, gender, alcohol and smoking habits and polymorphisms;
a
P < 0.05 vs control. OR: Odds ratio.