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. 2018 Oct 21;24(39):4462–4471. doi: 10.3748/wjg.v24.i39.4462

Table 3.

Distribution of the clinical-histopathological parameters in relation to the polymorphisms in the genes GSTP1, GSTT1, and GSTM1 in patients with colorectal cancer n (%)

Models Genotypes Tumor progression (TNM) (n = 201)
Primary site
Non-advanced 61 (31) Advanced 140 (69) OR1 95%CI Colon Rectum OR1 95%CI
GSTP1
Codominant A/A 31 (51) 62 (44) 1.00 42 (46) 65 (46) 1.00
A/G 23 (38) 65 (47) 1.37 (0.70-2.66) 38 (41) 64 (45) 0.96 (0.54-1.72)
G/G 6 (10) 11 (8) 1.14 (0.37-3.50) 11 (12) 12 (8) 0.73 (0.29-1.85)
Dominant A/A 31 (51) 62 (44) 1.00 42 (46) 65 (46) 1.00
A/G-G/G 29 (48) 76 (55) 1.32 (0.71-2.48) 49 (53) 76 (53) 0.91 (0.53-1.57)
Recessive A/A-A/G 54 (90) 127 (92) 1.00 80 (87) 129 (91) 1.00
G/G 6 (10) 11 (8) 1.00 (0.34-2.95) 11 (12) 12 (8) 0.74 (0.31-1.81)
Overdominant A/A-G/G 37 (61) 73 (52) 1.00 53 (58) 77 (54) 1.00
A/G 23 (38) 65 (47) 1.34 (0.70-2.56) 38 (41) 64 (45) 1.02 (0.59-1.77)
Aditivo - - - 1.18 (0.73-1.92) - - 0.89 (0.59-1.34)
GSTT1
+/+ 47 (78) 47 (78) 1.00 78 (85) 114 (80) 1.00
0/0 13 (22) 20 (14) 0.57 (0.26-1.27) 13 (14) 27 (19) 1.47 (0.71-3.06)
GSTM1
+/+ 34 (56) 53 (38) 1.00 45 (49.5) 55 (39) 1.00
0/0 26 (43) 85 (61) 2.33 (1.23-4.41)a 46 (50.5) 86 (61) 1.49 (0.87-2.57)
1

OR adjusted for age, gender, alcohol and smoking habits and polymorphisms;

a

P < 0.05 vs control. OR: Odds ratio.