Table 3.
Models | Genotypes |
Tumor progression (TNM) (n = 201) |
Primary site |
||||||
Non-advanced 61 (31) | Advanced 140 (69) | OR1 | 95%CI | Colon | Rectum | OR1 | 95%CI | ||
GSTP1 | |||||||||
Codominant | A/A | 31 (51) | 62 (44) | 1.00 | 42 (46) | 65 (46) | 1.00 | ||
A/G | 23 (38) | 65 (47) | 1.37 | (0.70-2.66) | 38 (41) | 64 (45) | 0.96 | (0.54-1.72) | |
G/G | 6 (10) | 11 (8) | 1.14 | (0.37-3.50) | 11 (12) | 12 (8) | 0.73 | (0.29-1.85) | |
Dominant | A/A | 31 (51) | 62 (44) | 1.00 | 42 (46) | 65 (46) | 1.00 | ||
A/G-G/G | 29 (48) | 76 (55) | 1.32 | (0.71-2.48) | 49 (53) | 76 (53) | 0.91 | (0.53-1.57) | |
Recessive | A/A-A/G | 54 (90) | 127 (92) | 1.00 | 80 (87) | 129 (91) | 1.00 | ||
G/G | 6 (10) | 11 (8) | 1.00 | (0.34-2.95) | 11 (12) | 12 (8) | 0.74 | (0.31-1.81) | |
Overdominant | A/A-G/G | 37 (61) | 73 (52) | 1.00 | 53 (58) | 77 (54) | 1.00 | ||
A/G | 23 (38) | 65 (47) | 1.34 | (0.70-2.56) | 38 (41) | 64 (45) | 1.02 | (0.59-1.77) | |
Aditivo | - | - | - | 1.18 | (0.73-1.92) | - | - | 0.89 | (0.59-1.34) |
GSTT1 | |||||||||
+/+ | 47 (78) | 47 (78) | 1.00 | 78 (85) | 114 (80) | 1.00 | |||
0/0 | 13 (22) | 20 (14) | 0.57 | (0.26-1.27) | 13 (14) | 27 (19) | 1.47 | (0.71-3.06) | |
GSTM1 | |||||||||
+/+ | 34 (56) | 53 (38) | 1.00 | 45 (49.5) | 55 (39) | 1.00 | |||
0/0 | 26 (43) | 85 (61) | 2.33 | (1.23-4.41)a | 46 (50.5) | 86 (61) | 1.49 | (0.87-2.57) |
OR adjusted for age, gender, alcohol and smoking habits and polymorphisms;
P < 0.05 vs control. OR: Odds ratio.