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. Author manuscript; available in PMC: 2018 Oct 22.
Published in final edited form as: N Engl J Med. 2015 Oct 15;373(16):1531–1540. doi: 10.1056/NEJMsa1504267

Table 2.

National Estimates of Emergency Department Visits for Dietary Supplement Adverse Events by Product Category, Excluding Unsupervised Child Ingestions—United States, 2004–2013*

Product Category Emergency Department Visits for Dietary Supplement Adverse Events
National Estimate
% 95% Confidence Interval
Herbals/Complementary Nutritionals 65.9 63.2 – 68.5
 Weight Loss 25.5 23.1 – 27.9
 Energy 10.0 8.0 – 11.9
 Sexual Enhancement 3.4 2.4 – 4.3
 Cardiovascular Health 3.1 2.3 – 3.9
 Sleep, Sedation or Anxiolysis 2.9 2.1 – 3.6
 Laxative 2.5 1.8 – 3.3
 Bodybuilding 2.2 1.1 – 3.2
 Immunity Infection/Cold 2.2 1.5 – 2.9
 Pain/Arthritis Relief 1.7 1.2 – 2.3
 Detoxification or Cleansing 1.4 0.7 – 2.0
 Skin or Hair Health 1.0 0.6 – 1.4
 Microbial Additive 0.8 0.4 – 1.3
 Other Specified Products 4.8 3.7 – 5.9
 Unspecified Products 4.4 3.3 – 5.4
Micronutrients 31.8 29.2 – 34.3
 Multivitamins or Unspecified Vitamins 16.8 15.1–18.5
 Iron 4.7 3.4 – 6.1
 Calcium 3.4 2.5 – 4.3
 Potassium 2.0 1.2 – 2.7
 Other Single-ingredient Vitamins or Minerals 4.9 3.6 – 6.2
>1 Supplement Product§ 2.4 1.4 – 3.3
Total 100.0 N/A
*

National Electronic Injury Surveillance System–Cooperative Adverse Drug Event Surveillance project, CDC.

For definitions and specific products please see Tables S1 and S2 in Supplementary Appendix.

National estimate may be unstable (based on <20 cases).

§

Of 71 cases implicating two supplement products, 45 cases implicated two herbal/complementary nutritional products, 6 cases implicated two micronutrient products, and 20 cases implicated both a micronutrient and herbal/complementary nutritional product.