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. Author manuscript; available in PMC: 2018 Oct 22.
Published in final edited form as: N Engl J Med. 2015 Oct 15;373(16):1531–1540. doi: 10.1056/NEJMsa1504267

Table 3.

National Estimates of Symptoms Documented in Emergency Department Visits for Dietary Supplement Adverse Events from Selected Dietary Supplement Product Categories, Excluding Unsupervised Child Ingestions—United States, 2004–2013*

Symptoms Emergency Department Visits for Dietary Supplement Adverse Events
National Estimate
% 95% Confidence Interval
Supplements for Weight Loss
 Palpitations, Chest Pain, and/or Tachycardia 42.9 38.4 – 47.4
 Headache, Dizziness, Presyncope, and/or Other Acute Sensory or Motor Impairment 32.1 26.2 – 38.0
 Nausea, Vomiting, and/or Abdominal Pain 18.6 13.6 – 23.7
 Mild to Moderate Allergic Reaction 14.3 9.5 – 19.2
 Anxiety/Feeling Jittery 12.9 10.2 – 15.5
 Severe Allergic Reaction 4.2 2.3 – 6.2
 Seizure, Syncope, and/or Loss of Consciousness 4.0 2.1 – 5.8
Supplements for Energy
 Palpitations, Chest Pain, and/or Tachycardia 46.0 39.1 – 52.9
 Headache, Dizziness, Presyncope, and/or Other Acute Sensory or Motor Impairment 34.3 25.7 – 43.0
 Nausea, Vomiting, and/or Abdominal Pain 23.0 15.9 – 30.1
 Anxiety/Feeling Jittery 17.5 11.4 – 23.7
Micronutrients (Excluding Iron, Calcium, and Potassium)
 Mild to Moderate Allergic Reaction 40.6 34.2 – 47.1
 Pill-induced Dysphagia or Globus 23.6 17.1 – 30.0
 Airway Obstruction (Due to Choking) 19.4 10.7 – 28.0
 Headache, Dizziness, Presyncope, and/or Other Acute Sensory or Motor Impairment 7.0 3.8 – 10.2
 Nausea, Vomiting, and/or Abdominal Pain 6.5 3.2 – 9.7
 Severe Allergic Reaction 6.1 3.7 – 8.6
 Palpitations, Chest Pain, and/or Tachycardia 3.8 2.2 – 5.4
*

National Electronic Injury Surveillance System–Cooperative Adverse Drug Event Surveillance project, CDC.

Symptoms are not mutually exclusive; totals may be >100%.