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. 2018 Sep 4;115(8):1580–1588. doi: 10.1016/j.bpj.2018.08.038

Figure 5.

Figure 5

Thick-filament extensibility in passively stretched muscle compared to that in active muscle. (A) The spacing of the 2.86 nm reflection as a function of total passive tension (filled circles) and active tension (open circles) in passively stretched and actively contracting EDL muscle, respectively. The thick-filament-extensibility curve from actively contracting muscle has a similar shape to that of passive stretched muscle, but curves do not overlap. (B) The 2.86 nm myosin-reflection changes as a function of titin-based passive tension in passively stretched muscle were indistinguishable from the spacing changes in actively contracting EDL muscle as a function of active tension. The fits to a Hill model are shown (heavy line) along with 95% confidence levels (dotted lines).