Table 1.
The demographic, cognitive and neuropathological information
| Variables | NC | SMC | T/χ2- value | P value |
|---|---|---|---|---|
| Number | 40 | 44 | ||
| Demographic characteristics | ||||
| Age, y, mean (SD) | 75.10±5.39 | 73.78±5.81 | 1.08 | 0.28 |
| Female, n (%) | 22/18 | 24/20 | 0.002 | 0.57 |
| Education (y), mean (SD) | 16.70±2.39 | 16.66±2.60 | 0.08 | 0.94 |
| Family, yes/no | 23/17 | 14/30 | 7.28 | 0.03* |
| APOE | 27/13 | 35/9 | 1.57 | 0.16 |
| CSF | ||||
| Aβ1–42 (pg/ml) | 1389.89±755.77 | 1552.79±683.30 | -0.75 | 0.46 |
| T-Tau (pg/ml) | 235.32±83.46 | 259.52±68.76 | -1.05 | 0.30 |
| P-Tau181 (pg/ml) | 21.80±8.80 | 23.50±6.10 | -0.73 | 0.47 |
| Neuropsychiatric Scores | ||||
| CCI | 31.37±8.30 | |||
| GDS | 0.68±0.89 | 1.14±0.90 | -2.36 | 0.02* |
| General mental status | ||||
| MMSE | 29.05±1.18 | 29.36±0.75 | -1.44 | 0.15 |
| Memory function | ||||
| WMS-LM immediate | 15.00±2.67 | 15.25±3.01 | -0.39 | 0.70 |
| WMS-LM delay | 14.38±2.83 | 14.23±3.40 | 0.22 | 0.83 |
| AVLT sum of trials 1–5 | 44.95±9.43 | 48.84±9.59 | -1.86 | 0.07 |
| AVLT30 | 7.18±4.14 | 8.88±4.18 | -1.85 | 0.07 |
| Attention | ||||
| Log-transformed TMT-A | 1.50±0.12 | 1.48±0.14 | 0.59 | 0.55 |
| Decision-making function | ||||
| Log-transformed TMT-B | 1.79±0.16 | 1.84±0.17 | -1.36 | 0.18 |
| Language | ||||
| BNT total | 28.94±1.05 | 28.52±1.50 | 1.14 | 0.26 |
| Category fluency | 21.75±4.06 | 22.20±5.02 | -0.45 | 0.65 |
| Visuospatial processing | ||||
| CDT | 4.85±0.36 | 4.86±0.35 | -0.18 | 0.86 |
| Ecog PT: memory | 1.53±0.41 | 1.94±0.60 | -3.73 | <0.001* |
| Ecog PT: global | 1.35±0.26 | 1.55±0.38 | -2.85 | 0.006* |
| Ecog Inf: memory | 1.24±0.40 | 1.59±0.59 | -3.18 | 0.002* |
| Ecog Inf: global | 1.22±0.34 | 1.43±0.52 | -2.15 | 0.03* |
Data are presented as means ± standard deviations.
Abbreviation: SMC Significant Memory Complaint, NC Normal Controls, GDS Geriatric Depression Scale, MMSE Mini-Mental State Examination, WMS-LM Wechsler Memory Scale Logical Memory, AVLT Auditory Verbal Learning Test, TMT Trail-Making Test, BNT Boston Naming Test, CDT Clock Drawing Test, E-Cog Measurement of Everyday Cognition, PT patient-based, Inf Informant-based;
*p<0.05, significant difference between NC and SMC
Notably: The CSF data in Table 1 only represents the subjects who had CSF sample.