Table 2.
Associations between cancer survivorship and covariates, and statin initiation among the high cardiovascular risk cohort
| Total n | Initiates statin n (%) | Crude OR (95% CI) | p-value | Adjusteda OR (95% CI) | p-value | |
|---|---|---|---|---|---|---|
| Cancer status (binary) | ||||||
| Non-cancer | 113,035 | 26,606 (23.54) | 1 | 0.443 | 1 | |
| Cancer survivor | 4202 | 968 (23.04) | 0.97 (0.90–1.05) | 0.98 (0.92–1.05) | 0.626 | |
| Sex | ||||||
| Males | 82,923 | 18,902 (22.79) | 1 | < 0.001 | 1 | < 0.001 |
| Females | 34,314 | 8672 (25.27) | 1.15 (1.11–1.18) | 1.19 (1.15–1.23) | ||
| Age (years) | ||||||
| 40–49 | 5437 | 1301 (23.93) | 1 | < 0.001 | 1 | < 0.001 |
| 50–59 | 27,489 | 6402 (23.29) | 0.97 (0.90–1.04) | 0.96 (0.89–1.03) | ||
| 60–69 | 52,662 | 12,760 (24.23) | 1.02 (0.92–1.12) | 1.00 (0.90–1.10) | ||
| 70–79 | 28,478 | 6624 (23.26) | 0.96 (0.87–1.06) | 0.92 (0.83–1.01) | ||
| 80+ | 3171 | 487 (15.36) | 0.58 (0.47–0.71) | 0.53 (0.43–0.65) | ||
| BMI (kg/m2) | ||||||
| < 18.5 | 948 | 136 (14.35) | 0.62 (0.53–0.73) | < 0.001 | ||
| 18.5–25 | 28,421 | 6050 (21.29) | 1 | |||
| ≥ 25 | 84,659 | 20,779 (24.54) | 1.2 (1.17–1.24) | |||
| Missing n (%) | 3213 (2.74) | |||||
| Cholesterol (mmol/L) | ||||||
| Normal (< 5) | 22,469 | 2910 (12.95) | 1 | < 0.001 | ||
| Moderate - High (5–8) | 88,274 | 22,838 (25.87) | 2.36 (2.25–2.49) | |||
| High (> 8) | 3435 | 1750 (50.95) | 7.1 (6.48–7.78) | |||
| Missing n (%) | 3059 (2.61) | |||||
| Smoking status | ||||||
| Never smoker | 30,500 | 6863 (22.5) | 1 | < 0.001 | ||
| Ex-smoker | 48,627 | 11,971 (24.62) | 1.12 (1.08–1.17) | |||
| Current smoker | 38,065 | 8738 (22.96) | 1.03 (0.97–1.09) | |||
| Missing n (%) | 45 (0.04) | |||||
| Alcohol status | ||||||
| Non-drinker | 18,881 | 4598 (24.35) | 1 | < 0.001 | ||
| Ex-drinker | 4241 | 1064 (25.09) | 1.04 (0.94–1.15) | |||
| Current drinker | ||||||
| light | 42,625 | 10,455 (24.53) | 1.01 (0.96–1.06) | |||
| moderate | 6128 | 1475 (24.07) | 0.98 (0.91–1.06) | |||
| heavy | 9483 | 2039 (21.50) | 0.85 (0.77–0.94) | |||
| amount unknown | 4310 | 1009 (23.41) | 0.95 (0.85–1.06) | |||
| Missing n (%) | 31,569 (26.93) | |||||
| Medical history | ||||||
| Diabetes | 5495 | 1853 (33.72) | 1.7 (1.57–1.85) | < 0.001 | ||
| Chronic kidney disease | 5833 | 1568 (26.88) | 1.21 (1.11–1.31) | < 0.001 | ||
| Chronic liver disease | 2050 | 453 (22.10) | 0.92 (0.83–1.02) | 0.120 | ||
| Index of Multiple Deprivation quintile | ||||||
| 1 (least deprived) | 13,483 | 3133 (23.24) | 1 | < 0.001 | ||
| 2 | 14,204 | 3143 (22.13) | 0.94 (0.75–1.17) | |||
| 3 | 14,756 | 3510 (23.79) | 1.03 (0.82–1.29) | |||
| 4 | 59,358 | 13,626 (22.96) | 0.98 (0.84–1.16) | |||
| 5 (most deprived) | 15,436 | 4162 (26.96) | 1.22 (0.95–1.56) | |||
| Calendar year | ||||||
| 2005–07 | 23,643 | 6257 (26.46) | 1 | < 0.001 | ||
| 2008–10 | 50,030 | 11,461 (22.91) | 0.83 (0.80–0.86) | |||
| 2011–13 | 43,564 | 9856 (22.62) | 0.81 (0.78–0.84) | |||
aAdjusted for a priori confounders (age and gender). No other covariates changed the association between cancer survivorship and statin initiation by more than 10%