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Inhibition unmasked at high PFL concentrations. (A) Sample traces as in Fig. 2E with 300 μM PFL cotreatment, repeated. Arrow indicates comparison in graph B. (Scale bars, 2 μA vs. 2 min.) (B) Acute inhibition of GLIC M1-205 variants by 300 μM PFL, calculated as percent difference between cotreatment and posttreatment currents. Significance is relative to WT, one-way analysis of variance, n = 4 to 10 (*P < 0.05; **P < 0.01; ****P < 0.0001).
