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. 2018 Oct 1;115(42):10744–10749. doi: 10.1073/pnas.1806796115

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Copyright © 2018 the Author(s). Published by PNAS.

This open access article is distributed under Creative Commons Attribution-NonCommercial-NoDerivatives License 4.0 (CC BY-NC-ND).

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Fig. 4. — Decreased dendritic spine density of mPFC neurons in Rai1^STOP/+ mice. (A) Representative image of WT (Rai1^+/+;Thy1^EGFP) and Rai1^STOP/+;Thy1^EGFP main apical dendritic trunk of layer V pyramidal neurons at layers II/III. (Scale bar, 5 μm.) (B) Rai1^STOP/+ mice (three mice, n = 124 segments) showed a decreased dendritic spine density in the mPFC compared with their WT littermates (three mice, n = 128 segments; mean ± SEM; *P < 0.05; t test). (C) Rai1^STOP/+ mice showed decreased spine density in both ACC (WT, n = 71 segments; Rai1^STOP/+, n = 68 segments) and PL (WT, n = 53 segments; Rai1^STOP/+, n = 60 segments) compared with their WT littermates (mean ± SEM; *P < 0.05; t test). (D) Rai1^STOP/+ mice showed decreased spine density in both anterior mPFC (WT, n = 60 segments; Rai1^STOP/+, n = 56 segments) and posterior mPFC (WT, n = 64 segments; Rai1^STOP/+, n = 72 segments) compared with their WT littermates (mean ± SEM; *P < 0.05, ***P < 0.001; t test). Anterior mPFC showed a greater loss of spine density.