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. 2018 Oct 1;115(42):E9899–E9908. doi: 10.1073/pnas.1805351115

Fig. 7.

Fig. 7.

HSP90 is required for DLK-dependent synaptic terminal overgrowth at the Drosophila NMJ. (A) Representative images of third-instar larva muscle 4 NMJs of wild-type (WT); hiw; highwireND9,dvglut-Gal4;UAS-wallenda-RNAi (hiw;wnd-RNAi); and highwireND9,dvglut-Gal4;UAS-hsp83-RNAi (hiw;hsp83-RNAi) animals stained for the presynaptic bouton marker DVGLUT (green) and nerve membrane marker HRP (red). (Scale bar: 25 µm.) (B) Quantification of A (mean ± SEM). n = 18–23 NMJs total from at least four animals per genotype; one-way ANOVA with Tukey’s multiple comparisons test; DF = 78, F = 128.6. P = 0.69 WT vs. hiw;wnd-RNAi; P = 0.30 WT vs. hiw;hsp83-RNAi. ***P < 0.0001 WT vs. hiw. ns, not significant.