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. 2018 Sep 27;40(6):3416–3426. doi: 10.3892/or.2018.6741

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Copyright: © Xie et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 7. — The effects of CDK1 on cell proliferation and the cell cycle. (A) The mRNA level of CDK1 was induced in the siRNA-CDK1-treated group compared with the siRNA-NC-treated group in MDA-MB-231 and HCC-1937 cells. ***P<0.001. (B) MTT assay colony forming assays showed that silencing of CDK1 suppressed cell proliferation. ***P<0.001. (C) Colony forming assays showed that silencing of CDK1 suppressed the colony forming ability of cells. ***P<0.001 (D) Silencing of CDK1 disrupted the cell cycle. *P<0.05, **P<0.01, ***P<0.001. siRNA, small interfering RNA; CDK, cyclin-dependent kinase; NC, negative control.