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. 2018 Sep 27;40(6):3447–3457. doi: 10.3892/or.2018.6740

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Copyright: © Lei et al.

This is an open access article distributed under the terms of the Creative Commons Attribution-NonCommercial-NoDerivs License, which permits use and distribution in any medium, provided the original work is properly cited, the use is non-commercial and no modifications or adaptations are made.

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Figure 1. — Targeting TrxR inhibits growth of liver cancer cells. (A) HepG2 and (B) Hepa1-6 cells were treated with designated concentrations of AA1 for 24 or 48 h and cell viability was determined using the MTT assay. Following treatment with AA1, the activity of TrxR in (C) HepG2 and (D) Hepa1-6 cells was tested using a 3-carboxy-4-nitrophenyl disulfide assay and measuring absorbance at 420 nm. Data are expressed as the mean ± standard deviation from at least three independent experiments. *P<0.05 and **P<0.01. TrxR, thioredoxin reductase; AA1, chloro(triethylphosphine)gold(I); OD, optical density.