Figure 1.
Plantar incision (PI)-induced mechanical allodynia, thermal hyperalgesia, and upregulation of TLR4 in L4/L5 DRGs in rats. Behavioral data showing reduction in paw withdrawal threshold (a) and paw withdrawal latency (b) following PI. *P < 0.05; **P < 0.01; ***P< 0.001 versus baseline value, two-way ANOVA. BL: baseline. (c) Western blotting data showing increased expression of TLR4 in ipsilateral L4/L5 DRGs following PI. *P < 0.05; **P < 0.01 versus sham group, one-way ANOVA. TLR4: Toll-like receptor-4.