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. 2018 Oct 18;14:1744806918807050. doi: 10.1177/1744806918807050

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© The Author(s) 2018

Creative Commons Non Commercial CC BY-NC: This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (http://www.creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 7. — Intraplantar injection of TAK-242 or PDTC inhibited the expressions of NF-κB p-p65, TNF-α, and IL-1β in injured plantar tissue and ipsilateral L4/L5 DRGs following PI. The PI-induced increased expressions of p-p65, TNF-α, and IL-1β in injured plantar tissue were inhibited by prior to s.c. injection of TAK-242 (a) or PDTC (b) around injured plantar tissue. The expressions of p-p65, TNF-α, and IL-1β in ipsilateral L4/L5 DRGs were reduced after PI by prior to s.c. injection of TAK-242 (c) or PDTC (d) around injured plantar tissue. *P < 0.05; **P < 0.01 versus sham + vehicle (veh) group; #P < 0.05; ##P < 0.01 versus PI + veh group, one-way ANOVA. TNF-α: tumor necrosis factor-alpha; IL-1β: interleukin-1 beta; PI: plantar incision; PDTC: ▪; TAK: ▪.