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. 2018 Jul 31;27(21):3813–3824. doi: 10.1093/hmg/ddy280

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© The Author(s) 2018. Published by Oxford University Press.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.

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Class II informed conditional analyses. EUR (A) and AA (B) SNP and classical HLA allele association signals after conditioning on the best class II model (EUR: HLA-DRB1^*15:01 + HLA-DQA^*01:02 + HLA-DQB^*02:01; AA: HLA-DRB1^*15:03 + HLA-DQA^*01:02 + HLA-DQA^*05:01). EUR (C) and AA (D) SNP and classical HLA allele association signals after conditioning on the best class II + I model (EUR: HLA-DRB1^*15:01 + HLA-DQA^*01:02 + HLA-DQB^*02:01 + HLA-B^*08:01; AA: HLA-DRB1^*15:03 + HLA-DQA^*01:02 + HLA-DQA^*05:01 + HLA-B^*08:01). EUR (E) and AA (F) SNP and classical HLA allele association signals after conditioning on the best overall HLA model (EUR: HLA-DRB1^*15:01 + HLA-DQA^*01:02 + HLA-DQB^*02:01 + HLA-DR3^*02:01 + HLA-B^*08:01 + HLA-B^*18:01; AA: HLA-DRB1^*15:03 + HLA-DQA^*01:02 + HLA-DQA^*02:01 + HLA-DQA^*05:01 HLA-DQA^*05:05 + HLA-DQB^*03:19 + HLA-DQB^*02:02 + HLA-B^*08:01 + HLA-C^*07:01).